医学计算公式
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FIB-4=年龄×AST / (PLT计数×√ALT)
AST：谷草转氨酶，或称门冬氨酸转氨酶
ALT：谷氨酸氨基转移酶，或称丙氨酸氨基转移酶
PLT计数：血小板计数
FIB-4指数用于评估慢性肝病患者肝纤维化程度。
| FIB-4 | 风险 | 说明 |
|---|---|---|
| <1.45 | 低风险 | 通常认为没有显著的肝纤维化 |
| 1.45~3.25 | 中风险 | 可能存在一定程度的肝纤维化 |
| >3.25 | 高风险 | 可能存在显著的肝纤维化或肝硬化 |
[1] Kim MN, Lee JH, Chon YE, et al. Fibrosis-4, aspartate transaminase-to-platelet ratio index, and gamma-glutamyl transpeptidase-to-platelet ratio for risk assessment of hepatocellular carcinoma in chronic hepatitis B patients: comparison with liver biopsy. Eur J Gastroenterol Hepatol. 2019 Sep 3.
[2] Hannes Hagström, Mats Talbäck, Anna Andreasson, Göran Walldius, Niklas Hammar. Repeated FIB-4 measurements can help identify individuals at risk of severe liver disease. Journal of Hepatology, 2020; DOI: 10.1016/j.jhep.2020.06.007
[3] Tseng TC, Choi J, Nguyen MH, et al. One-year Fibrosis-4 index helps identify minimal HCC risk in non-cirrhotic chronic hepatitis B patients with antiviral treatment. Hepatol Int. 2021 Feb;15(1):105-113.
